Concept
Molecular biology
Overview
Molecular biology is a branch of biology that seeks to understand the molecular structures and chemical processes that are the basis of biological activity within and between cells. It is centered largely on the study of nucleic acids (such as DNA and RNA) and proteins. It examines the structure, function, and interactions of these macromolecules as they orchestrate processes such as replication, transcription, translation, protein synthesis, and complex biomolecular interactions. The field of molecular biology is multi-disciplinary, relying on principles from genetics, biochemistry, physics, mathematics, and more recently computer science (bioinformatics).
Though cells and other microscopic structures had been observed in organisms as early as the 18th century, a detailed understanding of the mechanisms and interactions governing their behavior did not emerge until the 20th century, when technologies used in physics and chemistry had advanced sufficiently to permit their application in the biological sciences. The term 'molecular biology' was first used in 1945 by the English physicist William Astbury, who described it as an approach focused on discerning the underpinnings of biological phenomena—i.e. uncovering the physical and chemical structures and properties of biological molecules, as well as their interactions with other molecules and how these interactions explain observations of so-called classical biology, which instead studies biological processes at larger scales and higher levels of organization. In 1953, Francis Crick, James Watson, Rosalind Franklin, and their colleagues at the Medical Research Council Unit, Cavendish Laboratory, were the first to describe the double helix model for the chemical structure of deoxyribonucleic acid (DNA), which is often considered a landmark event for the nascent field because it provided a physico-chemical basis by which to understand the previously nebulous idea of nucleic acids as the primary substance of biological inheritance. They proposed this structure based on previous research done by Franklin, which was conveyed to them by Maurice Wilkins and Max Perutz. Their work led to the discovery of DNA in other microorganisms, plants, and animals.
The field of molecular biology includes techniques which enable scientists to learn about molecular processes. These techniques are used to efficiently target new drugs, diagnose disease, and better understand cell physiology. Some clinical research and medical therapies arising from molecular biology are covered under gene therapy, whereas the use of molecular biology or molecular cell biology in medicine is now referred to as molecular medicine.
Overview adapted from Wikipedia (CC BY-SA 4.0; see the article history for authors).
Possible passages
Found by search and not yet checked by a person; they may only mention the idea in passing.
In its primary stage, every germ consists of a substance that is uniform throughout, both in texture and chemical composition. The first step is the appearance of a difference between two parts of this substance; or, as the phenomenon is called in physiological language, a differentiation. Each of these differentiated divisions presently begins itself to exhibit some contrast of parts; and by and by these secondary…
Herbert Spencer, Essays on education and kindred subjects
States what Molecular biology is.
If this be true of chemical combinations, it is still more true of those far more complex combinations of elements which constitute organized bodies; and in which those extraordinary new uniformities arise which are called the laws of life. All organized bodies are composed of parts similar to those composing inorganic nature, and which have even themselves existed in an inorganic state; but the phenomena of life…
John Stuart Mill, A System of Logic, Ratiocinative and Inductive
States what Molecular biology is.
These latter commence by the doubling of the centrosome, a small spherical body alongside the nucleus. The two centrosomes thus obtained draw apart, attract the broken and doubled ends of the filament of which the original nucleus mainly consisted, and join them to form two fresh nuclei about which the two new cells are constructed which will succeed the first. Now, in their broad lines and in their external…
Henri Bergson, Creative Evolution
Close in meaning to Molecular biology; the term itself is not named.
Philosophers who discussed Molecular biology
Related ideas
- Genetics
- James Watson
- Virus
- Molecule
- Organism
- Mutation
- Nucleic acid
- Species
- Reproduction
- Evolutionary biology
- Bioinformatics
- Cell (biology)
- Gene
- DNA
- Developmental biology
- Biology
- Macromolecule
Place in the tradition
Part of Deductive-nomological model.